Clarithromycin: Inhibits protein synthesis by binding to 50S ribosomal subunit causing antibacterial activity. Lansoprazole. Half-Life: 0.9-1.5 hr. Bioavailability: 81-91% (empty stomach); 50-70% (30 minutes after food) Clearance Total Body: 0.7 L/hr/kg. Onset of action: 1-3 hr (gastric acid suppression) Renal: 517 mL/min. Metabolism: Gastric parietal cells: acidic pH converts lansoprazole to. Food does not affect the extent of bioavailability. Food does only slightly delay the onset of absorption of clarithromycin. 4.3 Contraindications. Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. Concomitant administration of clarithromycin and any of the following drugs is contraindicated: astemizole, cisapride, domperidone, pimozide and terfenadine. Clarithromycin is used to treat certain bacterial infections, such as pneumonia (a lung infection), bronchitis (infection of the tubes leading to the lungs), and infections of the ears, sinuses, skin, and throat. It also is used to treat and prevent disseminated Mycobacterium avium complex (MAC) infection [a type of lung infection that often affects people with human immunodeficiency virus. It does not take the place of talking to your doctor or pharmacist. All medicines have benefits and risks. Your doctor has weighed the risks of you taking Klacid against the benefits they expect. Medscape - Infection-specific dosing for clarithromycin, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Amoxicillin, clarithromycin, and omeprazole. Generic name: amoxicillin, clarithromycin, and omeprazole (a MOX i SIL in, kla RITH roe MYE sin, oh MEP ra zole) Brand name: Omeclamox-Pak Dosage forms: oral kit (500 mg-500 mg-20 mg) Drug class: H. pylori eradication agents Medically reviewed by Drugs.com on Sep 13, 2021. Written by Cerner Multum. Uses; Warnings; What to avoid Clarithromycin is an antibiotic. It's used to treat chest infections, such as pneumonia, skin problems such as cellulitis, and ear infections. It's also used to get rid of Helicobacter pylori, a bacteria that can cause stomach ulcers. Clarithromycin is sometimes used by people who have an allergy to penicillin and antibiotics similar to penicillin, like amoxicillin. Clarithromycin is used to treat a wide variety of bacterial infections.This medication can also be used in combination with anti-ulcer medications to treat certain types of stomach ulcers. It may. Clarithromycin 250 mg film-coated tablets - Summary of Product Characteristics (SmPC) by Aurobindo Pharma - Milpharm Ltd. This interaction does not appear to occur in paediatric HIV-infected patients taking clarithromycin suspension with zidovudine or dideoxyinosine. This interaction is unlikely when clarithromycin is administered via intravenous infusion. Phenytoin and Valproate. There. Clarithromycin has serious interactions with at least 215 different drugs. Clarithromycin has moderate interactions with at least 238 different drugs. Clarithromycin has minor interactions with at least 98 different drugs. This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell.